Inhibition of histone methyltransferases SUV39H1 and G9a leads to neuroprotection in an in vitro model of cerebral ischemia.

Link to publication

Schweizer S, Harms C, Lerch H, Flynn J, Hecht J, Yildirim F, Meisel A, Märschenz S.,
J Cereb Blood Flow Metab. 2015 Oct;35(10):1640-7

Histone Acetylation and CREB Binding Protein Are Required for Neuronal Resistance against Ischemic Injury.

Link to publication

Yildirim F, Ji S, Kronenberg G, Barco A, Olivares R, Benito E, Dirnagl U, Gertz K, Endres M, Harms C, Meisel A., 
PLoS One. 2014; 9(4): e95465.

Targeting H3K4 trimethylation in Huntington disease.

Link to publication

Vashishtha M*, Ng CW*, Yildirim F*, Gipson TA, Kratter IH, Bodai L, Song W, Lau A, Labadorf A, Vogel-Ciernia A, Troncosco J, Ross CA, Bates GP, Krainc D, Sadri-Vakili G, Finkbeiner S, Marsh JL, Housman DE, Fraenkel E, Thompson LM.,
Proc Natl Acad Sci U S A. 2013; 110(32): E3027-36. doi: 10.1073/pnas.1311323110. Epub 2013 Jul 19. *co-first authorship

Extensive changes in DNA methylation are associated with expression of mutant huntingtin.

Link to publication

Ng CW, Yildirim F, Yap YS, Dalin S, Matthews BJ, Velez PJ, Labadorf A, Housman DE, Fraenkel E.,
Proc Natl Acad Sci U S A. 2013; 110(6): 2354-9. doi: 10.1073/pnas.1221292110. Epub 2013 Jan 22.

Poly-glutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1.

Link to publication

Riva L, Koeva M, Yildirim  F, Dinesh D, Mazor T, Duennwald ML, Fraenkel E.,
Journal of Huntington’s Disease. 2012; 1: 33-45.

Impact of actin filament stabilization on adult hippocampal and olfactory bulb neurogenesis.

Link to publication

Kronenberg G, Gertz K, Baldinger T, Kirste I, Eckart S, Yildirim F, Ji S, Heuser I, Schröck H, Hörtnagl H, Sohr R, Djoufack PC, Jüttner R, Glass R, Przesdzing I, Kumar J, Freyer D, Hellweg R, Kettenmann H, Fink KB, Endres M.,
J Neurosci. 2010; 30(9): 3419-31. 

Inhibition of histone deacetylation protects wildtype but not gelsolin-deficient mice from ischemic brain injury.

Link to publication

Yildirim F, Gertz K, Kronenberg G, Harms C, Fink KB, Meisel A, Endres M.,
Exp Neurol. 2008; 210: 531-42.

Inhibition of histone deacetylation protects wild-type but not gelsolin-deficient neurons from oxygen/glucose deprivation.

Link to publication

Meisel A*, Harms C*, Yildirim F*, Bosel J, Kronenberg G, Harms U, Fink KB, Endres M.,
J Neurochem. 2006; 98: 1019-31. *co-first authorship